Contractions of ex-vivo mouse bladder driven by activation of channelrhodopsin-2 expressed in urothelial cells

Abstract Signaling molecules released from the urothelium by mechanical stretch are known to play a sensory role in bladder contractions via neuronal signaling. It is also theorized that these molecules released from the urothelium could act locally to induce urothelial cell-mediated local bladder c...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Firoj Alom, Kyle Joseph Ratcliff, Bhavana Talluri, Aaron D. Mickle
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-10-01
Subjects:	Urothelium ATP Acetylcholine Detrusor smooth muscle Bladder Optogenetics
Online Access:	https://doi.org/10.1038/s41598-025-18216-2