Prediction of the pharmacokinetics, pharmacodynamics and efficacy of a monoclonal antibody, using a physiologically based pharmacokinetic FcRn model.

Although advantages of physiologically based pharmacokinetic models (PBPK) are now well established, PBPK models that are linked to pharmacodynamic (PD) models to predict pharmacokinetics (PK), PD and efficacy of monoclonal antibodies (mAbs) in humans are uncommon. The aim of this study was to devel...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Manoranjenni eChetty, Linzhong eLi, Rachel eRose, Krishna eMachavaram, Masoud eJamei, Amin eRostami-Hodjegan, Iain eGardner
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2015-01-01
Subjects:	monoclonal antibodies PBPK models FcRn model PBPK PD efalizumab
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00670/full