α-klotho reduces susceptibility to osteoarthritis: evidence from cross-sectional studies and Mendelian randomization

BackgroundDespite extensive research, the association between serum α-klotho levels and osteoarthritis (OA) remains unclear, predominantly relying on findings from OA mouse models. This study used data from the National Health and Nutrition Examination Survey (NHANES) to conduct a cross-sectional st...

Full description

Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Zhao Li, Zhong Li, Qisheng Cheng, Xinlin Nie, Yu Cui, Bing Du, Taotao Ren, Yibo Xu, Teng Ma
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-11-01
Subjects:	α-klotho osteoarthritis NHANES Mendelian randomization causal effect
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2024.1450472/full