Polytopic fractional delivery of an HIV vaccine alters cellular responses and results in increased epitope breadth in a phase 1 randomized trialResearch in context

Summary: Background: Elicitation of broad immune responses is understood to be required for an efficacious preventative HIV vaccine. This Phase 1 randomized controlled trial evaluated whether administration of vaccine antigens separated at multiple injection sites vs combined, fractional delivery a...

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Bibliographic Details

Published in:	EBioMedicine
Main Authors:	Maurine D. Miner, Allan deCamp, Nicole Grunenberg, Stephen C. De Rosa, Andrew Fiore-Gartland, Katherine Bar, Paul Spearman, Mary Allen, Pei-Chun Yu, Bryce Manso, Nicole Frahm, Spyros Kalams, Lindsey Baden, Michael C. Keefer, Hyman M. Scott, Richard Novak, Hong Van Tieu, Georgia D. Tomaras, James G. Kublin, M. Juliana McElrath, Lawrence Corey, Ian Frank, Artur Kalichman, Paul Edlefsen, Mary Enama, John Hural, Renee Holt, Debora Dunbar, Dave Crawford, Ian Maki, Jan Johannessen, Scharla Estep, Yevgeny Grigoriev, Tamra Madenwald, Marianne Hansen, Drienna Holman, Ramey Fair, Genevieve Meyer, Anya Luke-Kilolam
Format:	Article
Language:	English
Published:	Elsevier 2024-02-01
Subjects:	HIV Fractionated delivery Polytopic vaccination Ad5 Epitope breadth
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396424000227