Effect of advanced glycation end products formed methylglyoxal, a food-borne dicarbonyl precursor, on the exacerbation of diabetic kidney disease by NOX4/Nrf2/NLRP3 inflammasome signaling pathway in db/db mice

Abstract Western-style diets, which are abundant in advanced glycation end products (AGEs), particularly methylglyoxal-derived AGE4, have been identified as contributing factors to the progression of diabetic kidney disease. The objective of this study was to elucidate the pathogenic mechanisms of A...

Full description

Bibliographic Details

Published in:	Applied Biological Chemistry
Main Authors:	Hee-Weon Lee, Min Ji Gu, Donghwan Kim, Eun Hee Han, Yoonsook Kim, Sang Keun Ha
Format:	Article
Language:	English
Published:	SpringerOpen 2025-07-01
Subjects:	Advanced glycation end products Methylglyoxal-derived AGEs Diabetic kidney diseases Inflammasome Oxidative stress
Online Access:	https://doi.org/10.1186/s13765-025-01011-y