Oxidative Stress-Induced Unscheduled CDK1–Cyclin B1 Activity Impairs ER–Mitochondria-Mediated Bioenergetic Metabolism

Targeting the activities of endoplasmic reticulum (ER)–mitochondrial-dependent metabolic reprogramming is considered one of the most promising strategies for cancer treatment. Here, we present biochemical subcellular fractionation, coimmunoprecipitation, gene manipulation, and pharmacologic evidence...

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Bibliographic Details

Published in:	Cells
Main Authors:	Jan-Gowth Chang, Ni Tien, Yi-Chih Chang, Meng-Liang Lin, Shih-Shun Chen
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Subjects:	apigenin ASM BCL-2/BCL-x<sub>L</sub> cyclin B1–CDK1 ER–mitochondria lipid raft
Online Access:	https://www.mdpi.com/2073-4409/10/6/1280