Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm

Lipid nanoparticle (LNP) is commonly used to deliver mRNA vaccines. Currently, LNP optimization primarily relies on screening ionizable lipids by traditional experiments which consumes intensive cost and time. Current study attempts to apply computational methods to accelerate the LNP development fo...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Wei Wang, Shuo Feng, Zhuyifan Ye, Hanlu Gao, Jinzhong Lin, Defang Ouyang
Format:	Article
Language:	English
Published:	Elsevier 2022-06-01
Subjects:	Lipid nanoparticle Ionizable lipid mRNA Vaccine Formulation prediction Machine learning
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383521004597