Evaluation of Intra-Articular Amikacin Administration in an Equine Non-inflammatory Joint Model to Identify Effective Bactericidal Concentrations While Minimizing Cytotoxicity

Septic arthritis causes significant morbidity and mortality in veterinary and human clinical practice and is increasingly complicated by multidrug-resistant infections. Intra-articular (IA) antibiotic administration achieves high local drug concentrations but is considered off-label usage, and appro...

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Bibliographic Details

Published in:	Frontiers in Veterinary Science
Main Authors:	Lynn Pezzanite, Lyndah Chow, Dean Hendrickson, Daniel L. Gustafson, A Russell Moore, Jason Stoneback, Gregg M. Griffenhagen, Gabriella Piquini, Jennifer Phillips, Paul Lunghofer, Steven Dow, Laurie R. Goodrich
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Subjects:	intra-articular antibiotic aminoglycoside amikacin cartilage horse
Online Access:	https://www.frontiersin.org/articles/10.3389/fvets.2021.676774/full