Elevated SerpinB2 regulates MUC5AC expression via STAT6 signaling in nasal epithelial cells in allergic rhinitis

BackgroundSerpinB2 is expressed in airway epithelial cells in nasal polyps and asthma in association with Type-2 inflammation. Allergic rhinitis (AR) is similarly associated with Type-2 inflammation and mucus hypersecretion. MUC5AC has been reported to be regulated by IL-13 in nasal epithelial cells...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Jing Li, Qianbo Cui, Zhipeng Li, Ying Zhu, Jing Wang, Wei Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	SerpinB2 MUC5AC epithelial cell allergic rhinitis STAT6
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1669777/full