Interplay of protein and DNA structure revealed in simulations of the lac operon.

The E. coli Lac repressor is the classic textbook example of a protein that attaches to widely spaced sites along a genome and forces the intervening DNA into a loop. The short loops implicated in the regulation of the lac operon suggest the involvement of factors other than DNA and repressor in gen...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Luke Czapla, Michael A Grosner, David Swigon, Wilma K Olson
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Online Access:	http://europepmc.org/articles/PMC3572996?pdf=render