Development of a Discriminative Dissolution Method, Using In-Silico Tool for Hydrochlorothiazide and Valsartan Tablets

Hydrochlorothiazide (HTZ) and Valsartan (VAL) are poorly soluble drugs in BCS classes IV and II. This study aimed to develop a method to assess the dissolution profile of tablets containing HTZ (12.5 mg) and VAL (160 mg) as a fixed-dose combination, using in silico tools to evaluate products markete...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Rosmery Merma Leon, Michele Georges Issa, Marcelo Dutra Duque, Josiane Souza Pereira Daniel, Humberto Gomes Ferraz
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Subjects:
dissolution
in silico
simulations
DDDPlus
hydrochlorothiazide
valsartan
Online Access:https://www.mdpi.com/1999-4923/15/6/1735

Internet

https://www.mdpi.com/1999-4923/15/6/1735

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