Antigenic Site Immunodominance Redirection Following Repeat Variant Exposure

Human norovirus is a leading cause of acute gastroenteritis, driven by antigenic variants within the GII.4 genotype. Antibody responses to GII.4 vaccination in adults are shaped by immune memory. How children without extensive immune memory will respond to GII.4 vaccination has not been reported. He...

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Bibliographic Details
Published in:Viruses
Main Authors: Lisa C. Lindesmith, Paul D. Brewer-Jensen, Michael L. Mallory, Mark R. Zweigart, Samantha R. May, Daniel Kelly, Rachel Williams, Sylvia Becker-Dreps, Filemón Bucardo, David J. Allen, Judith Breuer, Ralph S. Baric
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Subjects:
norovirus
neutralizing antibody
blockade antibody
immunodominance
variants of concern
antigenic seniority
Online Access:https://www.mdpi.com/1999-4915/14/6/1293

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https://www.mdpi.com/1999-4915/14/6/1293

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