Endoplasmic reticulum stress and ubiquitin-proteasome system impairment in natural scrapie

Chronic accumulation of misfolded proteins such as PrPSc can alter the endoplasmic reticulum homeostasis triggering the unfolded protein response (UPR). In this pathogenic event, the molecular chaperones play an important role. Several reports in humans and animals have suggested that neurodegenerat...

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Bibliographic Details

Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Jenny Lozada Ortiz, Marina Betancor, Sonia Pérez Lázaro, Rosa Bolea, Juan J. Badiola, Alicia Otero
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Subjects:	prion prion diseases scrapie endoplasmic reticulum stress ubiquitin-proteasome system
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1175364/full