G12/13 signaling in asthma

Abstract Shortening of airway smooth muscle and bronchoconstriction are pathognomonic for asthma. Airway shortening occurs through calcium-dependent activation of myosin light chain kinase, and RhoA-dependent calcium sensitization, which inhibits myosin light chain phosphatase. The mechanism through...

Full description

Bibliographic Details
Published in:Respiratory Research
Main Authors: Elizabeth L. McDuffie, Reynold A. Panettieri, Charles P. Scott
Format: Article
Language:English
Published: BMC 2024-08-01
Subjects:
Airway hyperresponsiveness
Airway remodeling
Anticholinergic agents
Asthma
Bronchoconstriction
Calcium sensitization
Online Access:https://doi.org/10.1186/s12931-024-02920-0

Internet

https://doi.org/10.1186/s12931-024-02920-0

Similar Items