Molecular insights into LINC complex architecture through the crystal structure of a luminal trimeric coiled-coil domain of SUN1

The LINC complex, consisting of interacting SUN and KASH proteins, mechanically couples nuclear contents to the cytoskeleton. In meiosis, the LINC complex transmits microtubule-generated forces to chromosome ends, driving the rapid chromosome movements that are necessary for synapsis and crossing ov...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Manickam Gurusaran, Jelle J. Biemans, Christopher W. Wood, Owen R. Davies
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Subjects:	LINC complex nuclear envelope SUN1 KASH5 X-ray crystallography molecular dynamics
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1144277/full