The AMPK/p27^Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells

Once believed to solely function as a cyclin-dependent kinase inhibitor, p27^Kip1 is now emerging as a critical mediator of autophagy, cytoskeletal dynamics, cell migration and apoptosis. During periods of metabolic stress, the subcellular location of p27<sup>Kip1</sup...

Full description

Bibliographic Details

Published in:	Cells
Main Authors:	Lauren K. McKay, James P. White
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Subjects:	p27 AMPK autophagy apoptosis aging Akt
Online Access:	https://www.mdpi.com/2073-4409/10/6/1430