Allosteric Modulators of Dopamine D₂ Receptors for Fine-Tuning of Dopaminergic Neurotransmission in CNS Diseases: Overview, Pharmacology, Structural Aspects and Synthesis

Allosteric modulation of G protein-coupled receptors (GPCRs) is nowadays a hot topic in medicinal chemistry. Allosteric modulators, i.e., compounds which bind in a receptor site topologically distinct from orthosteric sites, exhibit a number of advantages. They are more selective, safer and display...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Agnieszka A. Kaczor, Tomasz M. Wróbel, Damian Bartuzi
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Subjects:	allosteric modulation dopamine D<sub>2</sub> receptor G protein-couple receptors molecular modeling drug synthesis
Online Access:	https://www.mdpi.com/1420-3049/28/1/178