Computer-Aided Drug Design Boosts RAS Inhibitor Discovery

The Rat Sarcoma (RAS) family (NRAS, HRAS, and KRAS) is endowed with GTPase activity to regulate various signaling pathways in ubiquitous animal cells. As proto-oncogenes, RAS mutations can maintain activation, leading to the growth and proliferation of abnormal cells and the development of a variety...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Ge Wang, Yuhao Bai, Jiarui Cui, Zirui Zong, Yuan Gao, Zhen Zheng
Format:	Article
Language:	English
Published:	MDPI AG 2022-09-01
Subjects:	RAS inhibitor computer-aided drug design virtual screening molecular docking molecular dynamics simulation
Online Access:	https://www.mdpi.com/1420-3049/27/17/5710