Aloe-emodin attenuates hyperuricemia-induced renal injury in mice by mitigating inflammation and oxidative stress

BackgroundAloe-emodin (AOE), the principal anthraquinone constituent derived from aloe and rhubarb, exhibits antioxidant and anti-inflammatory properties, suggesting its therapeutic potential against hyperuricemia (HUA) and associated renal injury. Here, we investigated the potential of AOE in mitig...

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Bibliographic Details

Published in:	Frontiers in Nutrition
Main Authors:	Shengfeng Wang, Quanfeng Zhu, Chengcheng Zhang, Shuang Hu, Daqun Liu, Jiawen Yu, Xiao Liu, Yan Chen, Guojun Jiang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	aloe-emodin hyperuricemia renal injury oxidative stress inflammatory response PPAR/NF-κB signaling
Online Access:	https://www.frontiersin.org/articles/10.3389/fnut.2025.1677560/full