Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions

Abstract Behavioral challenges prompt alternating vigorous and reduced mobility – active, passive coping – that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elev...

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發表在:	Communications Biology
Main Authors:	Léo Michel, Denys Osypenko, Patricia Molina, Kadir A. Mutlu, Salvatore Lecca, Chihiro Hisatsune, Katsuhiko Mikoshiba, Toko Kikuchi, Emre Yaksi, Andrea Volterra, Manuel Mameli
格式:	Article
語言:	英语
出版:	Nature Portfolio 2025-07-01
在線閱讀:	https://doi.org/10.1038/s42003-025-08535-5