Pseudouridine synthases are proviral factors for Sindbis virus in insect and mammalian cells

ABSTRACT Alphaviruses are positive-sense, single-stranded RNA (+ssRNA) viruses transmitted by arthropod vectors to vertebrate hosts. Pseudouridine is the most prevalent RNA modification in the prototype alphavirus, Sindbis virus (SINV) genome, but the location, function, and the cellular machinery t...

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Bibliographic Details
Published in:mBio
Main Authors: Nicole Stark, Ram Podicheti, Lauren Garcia, Adela Krenz, Douglas B. Rusch, Irene L. G. Newton, Richard W. Hardy
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Subjects:
alphavirus
pseudouridine
proviral
Online Access:https://journals.asm.org/doi/10.1128/mbio.01329-25

Internet

https://journals.asm.org/doi/10.1128/mbio.01329-25

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