Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity

Patients who survive sepsis display prolonged immune dysfunction and heightened risk of secondary infection. CD4 T cells support a variety of cells required for protective immunity, and perturbations to the CD4 T cell compartment can decrease overall immune system fitness. Using the cecal ligation a...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Frances V. Sjaastad, Tamara A. Kucaba, Thamotharampillai Dileepan, Whitney Swanson, Cody Dail, Javier Cabrera-Perez, Katherine A. Murphy, Vladimir P. Badovinac, Thomas S. Griffith
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-08-01
Subjects:	sepsis immune suppression CD4 T cells memory IFN-gamma
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01786/full