A Comprehensive Analysis of the Thrombin Binding Aptamer Containing Functionalized Pyrrolo-2’-deoxycytidines

Aptamers constitute an answer for the growing need for targeted therapy development. One of the most well-known representatives of this group of compounds is thrombin binding aptamers (TBA) targeted towards thrombin. The TBA inhibitory activity is determined by its spatial arrangement, which consist...

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Bibliographic Details
Published in:Pharmaceuticals
Main Authors: Weronika Kotkowiak, Zofia Jahnz-Wechmann, Anna Pasternak
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Subjects:
G-quadruplex
thrombin binding aptamer
thermodynamics
circular dichroism
anticoagulant activity
anticancer agents
Online Access:https://www.mdpi.com/1424-8247/14/12/1326

Internet

https://www.mdpi.com/1424-8247/14/12/1326

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