Activation of PERK/eIF2α/ATF4/CHOP branch of endoplasmic reticulum stress response and cooperation between HIF-1α and ATF4 promotes Daprodustat-induced vascular calcification

Introduction: Vascular calcification is accelerated in patients with chronic kidney disease (CKD) and increases the risk of cardiovascular events. CKD is frequently associated with anemia. Daprodustat (DPD) is a prolyl hydroxylase inhibitor for the treatment of CKD-associated anemia that enhances er...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Andrea Tóth, Gréta Lente, Dávid Máté Csiki, Enikő Balogh, Árpád Szöőr, Béla Nagy, Viktória Jeney
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	chronic kidney disease (CKD) vascular calcification prolyl hydroxylase inhibitor hypoxia-inducible factor 1 endoplasmic reticulum stress ATF4
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1399248/full