Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711

Abstract Background Cathepsin K is an attractive therapeutic target for diseases in which bone resorption is excessive such as osteoporosis and osteoarthritis (OA). The current paper characterized the pharmacological profile of the potent and selective cathepsin K inhibitor, MIV-711, in vitro and in...

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發表在:	Journal of Translational Medicine
Main Authors:	Erik Lindström, Biljana Rizoska, Ian Henderson, Ylva Terelius, Markus Jerling, Charlotte Edenius, Urszula Grabowska
格式:	Article
語言:	英语
出版:	BMC 2018-05-01
主題:	Cathepsin K Osteoarthritis CTX-I NTX-I CTX-II Subchondral bone
在線閱讀:	http://link.springer.com/article/10.1186/s12967-018-1497-4