Engineered Jurkat Cells for Targeting Prostate-Specific Membrane Antigen on Prostate Cancer Cells by Nanobody-Based Chimeric Antigen Receptor

Background: Recently, modification of T cells with CAR has been an attractive approach for adoptive immunotherapy of cancers. Typically, CARs contain a scFv. Most often, scfvs are derived from a monoclonal antibody of murine origin and may be a trigger for host immune system that leads to the T-cell...

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Bibliographic Details

Published in:	Iranian Biomedical Journal
Main Authors:	Mahmoud Hassani, Fatemeh Hajari Taheri, Zahra Sharifzadeh, Arash Arashkia, Jamshid Hadjati, Wytske M. van Weerden, Shahriyar Abdoli, Mohammad Hossein Modarressi, Mohsen Abolhassani
Format:	Article
Language:	English
Published:	Pasteur Institute of Iran 2020-03-01
Subjects:	chimeric antigen receptor immunotherapy prostate cancer
Online Access:	http://ibj.pasteur.ac.ir/article-1-2922-en.pdf