Melatonin Prevents Transforming Growth Factor-β1-Stimulated Transdifferentiation of Renal Interstitial Fibroblasts to Myofibroblasts by Suppressing Reactive Oxygen Species-Dependent Mechanisms

Accumulating evidence suggests that the pineal hormone melatonin displays protective effects against renal fibrosis, but the mechanisms remain poorly understood. Here, we investigate the effect of the pineal hormone on transdifferentiation of renal fibroblasts to myofibroblasts invoked by transformi...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Jung-Yeon Kim, Jae-Hyung Park, Eon Ju Jeon, Jaechan Leem, Kwan-Kyu Park
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Subjects:	transforming growth factor-β1 fibroblast-myofibroblast transdifferentiation reactive oxygen species renal interstitial fibroblasts melatonin
Online Access:	https://www.mdpi.com/2076-3921/9/1/39