Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU)

BackgroundPrevious studies have revealed the role of dysregulated urokinase plasminogen activator (encoded by PLAU) expression and activity in several pathways associated with cancer progression. However, systematic investigation into the association of PLAU expression with factors that modulate PDA...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	S. M. Zahid Hosen, Md. Nazim Uddin, Zhihong Xu, Benjamin J. Buckley, Chamini Perera, Tony C. Y. Pang, Alpha Raj Mekapogu, Mohammad Ali Moni, Faiyaz Notta, Steven Gallinger, Ron Pirola, Jeremy Wilson, Marie Ranson, David Goldstein, Minoti Apte
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Subjects:	PLAU pancreatic stellate cells proliferation EMT stemness ECM degradation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1060957/full