Synthesis, molecular docking evaluation for LOX and COX-2 inhibition and determination of in-vivo analgesic potentials of aurone derivatives

In the current study, seven (7) aurone derivatives (ADs) were synthesized and employed to in-vitro LOX and COX-2 assays, in-vivo models of acetic acid-induced mice writhing, formalin-induced mice paw licking and tail immersion test to evaluate their analgesic potential at the doses of 10 mg and 20 m...

全面介紹

書目詳細資料

發表在:	Heliyon
Main Authors:	Muhammad Ikram, Ismail Shah, Haya Hussain, Ehsan Ullah Mughal, Nafeesa Naeem, Amina Sadiq, Yasir Nazir, Syed Wadood Ali Shah, Muhammad Zahoor, Riaz Ullah, Essam A. Ali, Muhammad Naveed Umar
格式:	Article
語言:	英语
出版:	Elsevier 2024-05-01
主題:	Aurone derivatives Analgesic IC50 Molecular docking Opioid mechanism LOX
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2405844024056895