Plasma lipidomic analysis reveals disruption of ether phosphatidylcholine biosynthesis and facilitates early detection of hepatitis B-related hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is the third deadliest malignant tumor worldwide. Most patients are initially diagnosed as HCC at advanced stages and are too late for radical treatment by surgery, resulting in poor prognosis. Over 50% of the HCC patients are caused by hepatitis B...

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Bibliographic Details

Published in:	Lipids in Health and Disease
Main Authors:	Yuyao Yuan, Donghao Yin, Xuemeng Yang, Di Liu, Hui Shan, Juan Luo, Xiuhui Li, Yuxin Yin
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Hepatitis B Hepatocellular carcinoma Plasma lipidomics Ether phosphatidylcholine Early detection Machine learning
Online Access:	https://doi.org/10.1186/s12944-025-02475-z