Interplay between bile acids, gut microbiota, and the tumor immune microenvironment: mechanistic insights and therapeutic strategies

The interplay between the gut microbiota, bile acid (BA) metabolism, and the tumor immune microenvironment (TIME) is a critical and rapidly advancing field in cancer immunology. Microbiota-transformed bile acids act as pivotal signaling molecules. This review systematically dissects how these BAs en...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yan Tong, Xiaojun Lou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	bile acids gut microbiota tumor immune microenvironment cancer immunotherapy immunometabolism
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1638352/full