Exploration of comprehensive two-dimensional liquid chromatography: Theoretical aspects and practical considerations - A tutorial

Comprehensive two-dimensional liquid chromatography (LC×LC) is a valuable tool for the analysis of very complex samples. LC×LC, which involves the coupling of two or more orthogonal separation systems, is a potential alternative to the conventional liquid-chromatography (1D-LC) approach. The profits...

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Bibliographic Details

Published in:	Journal of Chromatography Open
Main Authors:	Katia Arena, Francesco Cacciola, Roberto Laganà Vinci, Paola Dugo, Luigi Mondello
Format:	Article
Language:	English
Published:	Elsevier 2025-05-01
Subjects:	LC×LC Multidimensional chromatography Complex samples, method optimization
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772391725000209