Identifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses

Recurrent outbreaks of novel zoonotic coronavirus (CoV) diseases in recent years have highlighted the importance of developing therapeutics with broad-spectrum activity against CoVs. Because all CoVs use −1 programmed ribosomal frameshifting (−1 PRF) to control expression of key viral proteins, the...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Sneha Munshi, Krishna Neupane, Sandaru M. Ileperuma, Matthew T. J. Halma, Jamie A. Kelly, Clarissa F. Halpern, Jonathan D. Dinman, Sarah Loerch, Michael T. Woodside
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Subjects:	coronavirus SARS-CoV-2 programmed ribosomal frameshifting translation therapeutics
Online Access:	https://www.mdpi.com/1999-4915/14/2/177