I-Impute: a self-consistent method to impute single cell RNA sequencing data

Abstract Background Single-cell RNA-sequencing (scRNA-seq) is becoming indispensable in the study of cell-specific transcriptomes. However, in scRNA-seq techniques, only a small fraction of the genes are captured due to “dropout” events. These dropout events require intensive treatment when analyzin...

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Bibliographic Details

Published in:	BMC Genomics
Main Authors:	Xikang Feng, Lingxi Chen, Zishuai Wang, Shuai Cheng Li
Format:	Article
Language:	English
Published:	BMC 2020-11-01
Subjects:	scRNA-seq Imputation Self-consistency Cell subpopulation identification
Online Access:	http://link.springer.com/article/10.1186/s12864-020-07007-w