Extracellular succinate derived from ectopic milieu drives adhesion and implantation growth of ectopic endometrial stromal cells via the SUCNR1 signal in endometriosis

Abstract Background As a dual-function metabolite, succinate has emerged in cell function and plays a key signaling role in linking mitochondrial function to other cellular functions. Succinate accumulation in the cytoplasm is commonly associated with hypoxia in the microenvironment and immune cell...

Full description

Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Qi Tian, Jingyao Ruan, Yuning Wang, Yinping Xiao, Qi Cheng, Yun Chen, Mingqing Li, Kaikai Chang, Xiaofang Yi
Format:	Article
Language:	English
Published:	BMC 2024-01-01
Subjects:	Endometriosis Succinate Peritoneal mesothelial cell Endometrial stromal cells (ESCs) Macrophage SUCNR1
Online Access:	https://doi.org/10.1186/s12964-023-01415-7