Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation–induced surfactant secretion

Pulmonary surfactant is a lipoprotein complex lining the alveolar surface to decrease the surface tension and facilitate inspiration. Surfactant deficiency is often seen in premature infants and in children and adults with respiratory distress syndrome. Mechanical stretch of alveolar type 2 epitheli...

Full description

Bibliographic Details

Published in:	The Journal of Clinical Investigation
Main Authors:	Gui-Lan Chen, Jing-Yi Li, Xin Chen, Jia-Wei Liu, Qian Zhang, Jie-Yu Liu, Jing Wen, Na Wang, Ming Lei, Jun-Peng Wei, Li Yi, Jia-Jia Li, Yu-Peng Ling, He-Qiang Yi, Zhenying Hu, Jingjing Duan, Jin Zhang, Bo Zeng
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2024-03-01
Subjects:	Pulmonology
Online Access:	https://doi.org/10.1172/JCI174508