A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo.

Dietary factors regulate immunological function, but the underlying mechanisms remain elusive. Here we show that vitamin B9 is a survival factor for regulatory T (Treg) cells expressing high levels of vitamin B9 receptor (folate receptor 4). In vitamin B9-reduced condition in vitro, Treg cells could...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Jun Kunisawa, Eri Hashimoto, Izumi Ishikawa, Hiroshi Kiyono
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Online Access:	http://europepmc.org/articles/PMC3282783?pdf=render