Fluid shear stress enhances T cell activation through Piezo1

Abstract Background T cell activation is a mechanical process as much as it is a biochemical process. In this study, we used a cone-and-plate viscometer system to treat Jurkat and primary human T cells with fluid shear stress (FSS) to enhance the activation of the T cells through mechanical means. R...

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Bibliographic Details
Published in:BMC Biology
Main Authors: Jacob M. Hope, Jenna A. Dombroski, Rebecca S. Pereles, Maria Lopez-Cavestany, Joshua D. Greenlee, Samantha C. Schwager, Cynthia A. Reinhart-King, Michael R. King
Format: Article
Language:English
Published: BMC 2022-03-01
Subjects:
Fluid shear stress
Piezo1
T cells
Mechanotransduction
Online Access:https://doi.org/10.1186/s12915-022-01266-7

Internet

https://doi.org/10.1186/s12915-022-01266-7

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