Folic acid-modified celastrol nanoparticles: synthesis, characterization, anticancer activity in 2D and 3D breast cancer models

Celastrol is used in traditional Chinese medicine for treating cancers. However, its low water solubility and poor tumour selection represent major pitfalls for clinical application. In the present study, gold nanoparticle (AuNP) firstly was conjugated with PVP-co-2-dimethylaminoethyl methacrylate (...

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Bibliographic Details

Published in:	Artificial Cells, Nanomedicine, and Biotechnology
Main Authors:	Siukan Law, Albert Wingnang Leung, Chuanshan Xu
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2020-01-01
Subjects:	Celastrol PVP-co-2-dimethylaminoethyl methacrylate gold nanoparticles (AuNP) folic acid folate receptor-targeted celastrol AuNP (FCA) breast cancer
Online Access:	https://www.tandfonline.com/doi/10.1080/21691401.2020.1725025