Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia

Summary: There is evidence that ATM mutated in ataxia-telangiectasia (A-T) plays a key role in protecting against mitochondrial dysfunction, the mechanism for which remains unresolved. We demonstrate here that ATM-deficient cells are exquisitely sensitive to nutrient deprivation, which can be explai...

全面介紹

書目詳細資料

發表在:	iScience
Main Authors:	Abrey J. Yeo, Kok L. Chong, Magtouf Gatei, Dongxiu Zou, Romal Stewart, Sarah Withey, Ernst Wolvetang, Robert G. Parton, Adam D. Brown, Michael B. Kastan, David Coman, Martin F. Lavin
格式:	Article
語言:	英语
出版:	Elsevier 2021-01-01
主題:	Cell Biology Organizational Aspects of Cell Biology Functional Aspects of Cell Biology
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S258900422031169X