PPP2R1A silencing suppresses LUAD progression by sensitizing cells to nelfinavir-induced apoptosis and pyroptosis

Abstract Lung adenocarcinoma is a major public health problem with the low 5-year survival rate (15%) among cancers. Aberrant alterations of meiotic genes, which have gained increased attention recently, might contribute to elevated tumor risks. However, systematic and comprehensive studies based on...

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Bibliographic Details

Published in:	Cancer Cell International
Main Authors:	Yating Liu, Lianlian Ouyang, Shiyao Jiang, Lu Liang, Yuanbing Chen, Chao Mao, Yiqun Jiang, Li Cong
Format:	Article
Language:	English
Published:	BMC 2024-04-01
Subjects:	Lung adenocarcinoma Meiotic genes Prognostic model PPP2R1A Nelfinavir
Online Access:	https://doi.org/10.1186/s12935-024-03321-5