Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis

Abstract Background Resistance to pemetrexed (PEM), a rare chemotherapeutic agent that can efficiently cross the blood-brain barrier, limits the therapeutic efficacy for patients with lung cancer brain metastasis (BM). Aldo-keto reductase family 1 B10 (AKR1B10) was recently found to be elevated in l...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Wenzhe Duan, Wenwen Liu, Shengkai Xia, Yang Zhou, Mengyi Tang, Mingxin Xu, Manqing Lin, Xinyu Li, Qi Wang
Format:	Article
Language:	English
Published:	BMC 2023-08-01
Subjects:	Lung cancer Brain metastasis Chemotherapeutic resistance Pemetrexed AKR1B10 Warburg metabolism
Online Access:	https://doi.org/10.1186/s12967-023-04403-0