A pharmacovigilance study of the association between linaclotide/plecanatide and muscle spasms based on food and drug administration adverse event reporting system

BackgroundLinaclotide and plecanatide, as guanylate cyclase-C agonists, are effective treatments for irritable bowel syndrome with constipation and chronic idiopathic constipation. While their therapeutic benefits are well-established, the potential association between these drugs and the adverse re...

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Bibliographic Details
Published in:Frontiers in Pharmacology
Main Authors: Xue Fan, Yuan Li, Xiangchun Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1635792/full