Alternative oxidase promotes high iron tolerance in Candida albicans

ABSTRACT Although crucial for cellular functioning, iron is toxic when present in excess. Iron overload can create a labile iron pool (LIP) that harms the mitochondrion, resulting in disruption of oxidative respiration. Fungal pathogen C. albicans possesses an unconventional terminal oxidase [altern...

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發表在:	Microbiology Spectrum
Main Authors:	Rishabh Sharma, Andrew A. Gibb, Kelcie Barnts, John W. Elrod, Sumant Puri
格式:	Article
語言:	英语
出版:	American Society for Microbiology 2023-12-01
主題:	Candida albicans iron mitochondria reactive oxygen species alternative oxidase
在線閱讀:	https://journals.asm.org/doi/10.1128/spectrum.02157-23