Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system

IntroductionOligodendrocytes (OLs) are the myelin-forming cells of the central nervous system (CNS). Although OLs can be differentiated from human-induced pluripotent stem cells (hiPSCs), the in vitro modeling of axon myelination in human cells remains challenging. Brain microphysiological systems (...

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Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Authors:	July Carolina Romero, Cynthia Berlinicke, Sharon Chow, Yukan Duan, Yifei Wang, Xitiz Chamling, Lena Smirnova
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Subjects:	brain organoids CRISPR/Cas9 hiPSC fusion KI line neurodevelopment oligodendrogenesis myelination
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2022.1094291/full