Compartmentalization of anti-oxidant and anti-inflammatory gene expression in current and former smokers with COPD

Abstract Background Patients with chronic obstructive pulmonary disease (COPD) have high oxidative stress associated with the severity of the disease. Nuclear factor erythroid-2 related factor 2 (Nrf2)-directed stress response plays a critical role in the protection of lung cells to oxidative stress...

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Bibliographic Details
Published in:Respiratory Research
Main Authors: Venkataramana K. Sidhaye, Janet T. Holbrook, Alyce Burke, Kuladeep R. Sudini, Sanjay Sethi, Gerard J. Criner, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Rajesh Thimmulappa, Robert A. Wise, Shyam Biswal
Format: Article
Language:English
Published: BMC 2019-08-01
Subjects:
COPD
Smokers
Oxidative stress
Epithelial cells
Macrophages
Nrf2
Online Access:http://link.springer.com/article/10.1186/s12931-019-1164-1

Internet

http://link.springer.com/article/10.1186/s12931-019-1164-1

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