Alpha–lipoic acid supplementation improves pathological alterations in cellular models of Friedreich ataxia

Abstract Background Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts, cardiomyopathy, and an increased incidence of diabetes. The underlying pathophysiological mechanism of FRDA, driven by a...

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الحاوية / القاعدة:	Orphanet Journal of Rare Diseases
المؤلفون الرئيسيون:	Marta Talaverón-Rey, Diana Reche-López, Suleva Povea-Cabello, Mónica Álvarez-Córdoba, David Gómez-Fernández, Ana Romero-González, Paula Cilleros-Holgado, José Manuel Romero-Domínguez, Alejandra López-Cabrera, Rocío Piñero-Pérez, Susana González-Granero, José Manuel García-Verdugo, José A. Sánchez-Alcázar
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	BMC 2025-08-01
الموضوعات:	Friedreich ataxia Frataxin Mitochondria Iron accumulation Fibroblasts Induced neurons
الوصول للمادة أونلاين:	https://doi.org/10.1186/s13023-025-03990-z