Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins

Endothelial aging may be induced early in pathological situations. The uremic toxins indoxyl sulfate (IS) and p-cresol (PC) accumulate in the plasma of chronic kidney disease (CKD) patients, causing accelerated endothelial aging, increased cardiovascular events and mortality. However, the mechanisms...

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Bibliographic Details

Published in:	Toxins
Main Authors:	Fatima Guerrero, Andres Carmona, Maria Jose Jimenez, Teresa Obrero, Victoria Pulido, Juan Antonio Moreno, Sagrario Soriano, Alejandro Martín-Malo, Pedro Aljama
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Subjects:	aging indoxyl sulfate p-cresol endothelial cells endothelial dysfunction senescence
Online Access:	https://www.mdpi.com/2072-6651/13/10/738