Intranasal trivalent candidate vaccine elicits broad humoral and cellular immunity against pneumococcal pneumonia

Streptococcus pneumoniae is an important pathogen causing public health problems worldwide. Existing pneumococcal vaccines provide protection against only a few of the more than 100 pneumococcal serotypes, highlighting the urgent need for new preventive strategies. Pneumococcal protein vaccines have...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Fangyu Ren, Luyun Huang, Shilu Luo, Changjin Liu, Xianlian Chen, Xin Yao, Qiqi Linghu, Huaqin Hu, Xiaoyu Huang, Yuanqin Hu, Jian Huang, Xun Min
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Subjects:	Streptococcus pneumoniae trivalent vaccine humoral immunity cellular immunity protective efficacy
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2025.1563661/full