Patient-derived extracellular matrix from decellularized high-grade serous ovarian carcinoma tissues as a biocompatible support for organoid growth

High-grade serous ovarian cancer (HGSOC) is the most common clinically diagnosed ovarian cancer, often considered a fatal disease. Although current treatments appear to provide almost complete remission, the recurrence rate is still high. Here we present an innovative tissue engineering approach app...

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Bibliographic Details

Published in:	Translational Oncology
Main Authors:	Francesca Sensi, Giulia Spagnol, Ombretta Repetto, Edoardo D'Angelo, Andrea Biccari, Asia Marangio, Angela Guerriero, Astrid A. Mollo Castillo, Andrea Vogliardi, Eleonora Zanrè, Elisa Cimetta, Francesca Schiavi, Filippo Sperti, Matteo Marchetti, Orazio de Tommasi, Marco Noventa, Carlo Saccardi, Gaya Spolverato, Roberto Tozzi, Marco Agostini
Format:	Article
Language:	English
Published:	Elsevier 2025-11-01
Subjects:	Ovarian cancer Decellularization Patient-derived organoids Tumor microenvironment
Online Access:	http://www.sciencedirect.com/science/article/pii/S1936523325002542